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Sildenafil Citrate Chemical Structure:

Sildenafil Citrate Chemical Formula:C22H30N6O4S · C6H8O7

Sildenafil Citrate Molecular Weight : base: 474.6 g/mol
salt: 666.7 g/mol

How Sildenafil Citrate Tablets Works:

Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum.This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate(cGMP),leading to smooth relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection.Sildenafil Citrate is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5(PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with Sildenafil Citrate of Viagra and Generic Viagra on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, sildenafil citrate should not cause an erection. Sildenafil Citrate is metabolised by hepatic enzymes and excreted by both the liver and kidneys. If taken with a high fat meal, there may be a delay in absorption of Generic Viagra and Viagra and the net effect might be muted slightly as the plasma concentration will be lowered.

Who should take Sildenafil Citrate Tablets (Generic Viagra):

contraindications include:

When taking other nitric oxide donors, organic nitrites and nitrates, such as glyceryl trinitrate,sodium nitroprusside,amyl nitrite (Cheitlin et al 1999),intake of Sildenafil Citrate Tablets (Generic Viagra) should be avoided.

Sildenafil Citrate Tablets (Generic Viagra) should be avoided by men for whom sexual intercourse is inadvisable due to cardiovascular risk factors

Sildenafil Citrate Tablets (Generic Viagra) should not be taken by men suffering from severe hepatic impairment (decreased liver function)

Sildenafil Citrate Tablets (Generic Viagra) should not be taken by men who have severe impairment in renal function

Sildenafil Citrate Tablets (Generic Viagra) should not be taken by men having Hypotension (low blood pressure)

Sildenafil Citrate Tablets (Generic Viagra) should not be taken by men had Recent stroke or heart attack

Sildenafil Citrate Tablets (Generic Viagra) should not be taken by men suffering from Hereditary degenerative retinal disorders (including genetic disorders of retinal phosphodiesterases)

Sildenafil Citrate Tablets (Generic Viagra) Side effects:

Serious Sildenafil Citrate Side effects :priapism, severe hypotension , myocardial infarction, ventricular arrhythmias, sudden death, stroke and increased intraocular pressure.
Common Sildenafil Citrate side effects include: sneezing, headache, flushing, dyspepsia, prolonged erections, palpitations and photophobia.
Visual changes including blurring of vision and a curious bluish tinge have also been reported as sildenafil Citrate Tablets Side effects.

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